Overview

NCI Definition: A primary endometrial adenocarcinoma composed of neoplastic cells that form complex glandular patterns associated with budding and branching of the neoplastic glands. The neoplastic glands resemble those of the normal endometrium and may or may not be associated with sheet-like proliferation of malignant cells. Endometrioid adenocarcinoma is the most commonly seen morphologic variant of endometrial adenocarcinoma. [1]

Endometrial endometrioid adenocarcinomas most frequently harbor alterations in PTEN, PIK3CA, ARID1A, CTNNB1, and PIK3R1 [2].

Most Commonly Altered Genes in Endometrial Endometrioid Adenocarcinoma

PTEN Mutation, PIK3CA Mutation, ARID1A Mutation, ARID1A Frameshift, and CTNNB1 Mutation are the most common alterations in endometrial endometrioid adenocarcinoma [2].

Top Alterations in Endometrial Endometrioid Adenocarcinoma

Significant Genes in Endometrial Endometrioid Adenocarcinoma

CDK4 +

CDK6 +

ERBB2 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Synonyms
Endometrioid endometrial adenocarcinoma, Uterine Corpus Endometrioid Adenocarcinoma, Uterus endometrial adenocarcinoma endometrioid, Emdometrioid endomet. adenocar., Endometrium Carcinoma of the Endometrium, Uterine Corpus Endometrioid Carcinoma, Endometrioid Adenocarcinoma of the Endometrium
Parent(s)
Endometrioid Adenocarcinoma
Children
Oxyphilic Endometrial Endometrioid Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Variant with Squamous Differentiation, Endometrial Endometrioid Adenocarcinoma, Secretory Variant, Villoglandular Endometrial Endometrioid Adenocarcinoma, and Endometrial Endometrioid Adenocarcinoma with Spindled Epithelial Cells
OncoTree Name
Uterine Endometrioid Carcinoma
OncoTree Code
UEC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.