Overview

NCI Definition: A primary carcinoma of the endometrium characterized by the presence of malignant cells that lack evidence of differentiation. [1]

Endometrial undifferentiated carcinomas most frequently harbor alterations in PTEN, ARID1A, CTNNB1, TP53, and SMARCA4 [2].

Most Commonly Altered Genes in Endometrial Undifferentiated Carcinoma

PTEN Mutation (somatic), PTEN Mutation (germline), PTEN Mutation, ARID1A Mutation, and CTNNB1 Mutation are the most common alterations in endometrial undifferentiated carcinoma [2].

Top Alterations in Endometrial Undifferentiated Carcinoma

Significant Genes in Endometrial Undifferentiated Carcinoma

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

POLE +

Disease Details

Synonyms
Undifferentiated Endometrial Carcinoma
Parent(s)
Undifferentiated Carcinoma
OncoTree Name
Uterine Undifferentiated Carcinoma
OncoTree Code
UUC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.