NCI Definition: A primary carcinoma of the endometrium characterized by the presence of malignant cells that lack evidence of differentiation. [1]

Endometrial undifferentiated carcinomas most frequently harbor alterations in PTEN, ARID1A, CTNNB1, TP53, and SMARCA4 [2].

Most Commonly Altered Genes in Endometrial Undifferentiated Carcinoma

PTEN Mutation, ARID1A Mutation, CTNNB1 Mutation, TP53 Mutation, and SMARCA4 Mutation are the most common alterations in endometrial undifferentiated carcinoma [2].

Top Alterations in Endometrial Undifferentiated Carcinoma

Significant Genes in Endometrial Undifferentiated Carcinoma

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +


Disease Details

Undifferentiated Endometrial Carcinoma
Undifferentiated Carcinoma
OncoTree Name
Uterine Undifferentiated Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.