Overview

NCI Definition: A primary carcinoma of the endometrium characterized by the presence of malignant cells that lack evidence of differentiation. [1]

Endometrial undifferentiated carcinomas most frequently harbor alterations in TP53, PTEN, CTNNB1, ARID1A, and PIK3CA [2].

PTEN Mutation, TP53 Mutation, CTNNB1 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in endometrial undifferentiated carcinoma [2].

Significant Genes in Endometrial Undifferentiated Carcinoma

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.