NCI Definition: A primary carcinoma of the endometrium characterized by the presence of malignant cells that lack evidence of differentiation. [1]

Endometrial undifferentiated carcinomas most frequently harbor alterations in TP53, PTEN, CTNNB1, ARID1A, and PIK3CA [2].

Most Commonly Altered Genes in Endometrial Undifferentiated Carcinoma

PTEN Mutation, TP53 Mutation, CTNNB1 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in endometrial undifferentiated carcinoma [2].

Top Alterations in Endometrial Undifferentiated Carcinoma

Significant Genes in Endometrial Undifferentiated Carcinoma


Disease Details

Undifferentiated Endometrial Carcinoma
Undifferentiated Carcinoma
OncoTree Name
Uterine Undifferentiated Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.