NCI Definition: An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [1]

Endometrioid adenocarcinomas most frequently harbor alterations in PTEN, PIK3CA, ARID1A, CTNNB1, and PIK3R1 [2].

Most Commonly Altered Genes in Endometrioid Adenocarcinoma

PTEN Mutation, PIK3CA Mutation, ARID1A Mutation, ARID1A Frameshift, and CTNNB1 Mutation are the most common alterations in endometrioid adenocarcinoma [2].

Top Alterations in Endometrioid Adenocarcinoma

Significant Genes in Endometrioid Adenocarcinoma


MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Endometrioid Carcinoma of the Female Reproductive System, Endometrioid Carcinoma, Female Reproductive Endometrioid Carcinoma, Endometrioid Carcinoma of Female Reproductive System
Endometrioid Tumor
Ovarian Endometrioid Adenocarcinoma, Primary Peritoneal Endometrioid Adenocarcinoma, Uterine Ligament Endometrioid Adenocarcinoma, Cervical Endometrioid Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, and Endometrial Endometrioid Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.