NCI Definition: An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [1]

Endometrioid adenocarcinomas most frequently harbor alterations in PTEN, PIK3CA, ARID1A, CTNNB1, and PIK3R1 [2].

Most Commonly Altered Genes in Endometrioid Adenocarcinoma

PTEN Mutation (somatic), PTEN Mutation (germline), PTEN Mutation, PIK3CA Mutation (somatic), and PIK3CA Mutation are the most common alterations in endometrioid adenocarcinoma [2].

Top Alterations in Endometrioid Adenocarcinoma

Significant Genes in Endometrioid Adenocarcinoma


MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Endometrioid Carcinoma of Female Reproductive System, Endometrioid Carcinoma, Endometrioid Carcinoma of the Female Reproductive System, Female Reproductive Endometrioid Carcinoma
Endometrioid Tumor
Fallopian Tube Endometrioid Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Cervical Endometrioid Adenocarcinoma, and Uterine Ligament Endometrioid Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.