NCI Definition: An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [1]

Endometrioid adenocarcinomas most frequently harbor alterations in PTEN, PIK3CA, ARID1A, PIK3R1, and CTNNB1 [2].

Most Commonly Altered Genes in Endometrioid Adenocarcinoma

PTEN Mutation, PIK3CA Mutation, ARID1fs, CTNNB1 Mutation, and KRAS Mutation are the most common alterations in endometrioid adenocarcinoma [2].

Top Alterations in Endometrioid Adenocarcinoma

Significant Genes in Endometrioid Adenocarcinoma


MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Endometrioid Carcinoma of Female Reproductive System, Endometrioid Carcinoma of the Female Reproductive System, Female Reproductive Endometrioid Carcinoma, Endometrioid Carcinoma
Malignant Female Reproductive System Neoplasm
Endometrial Endometrioid Adenocarcinoma, Endometrioid Adenocarcinoma, Variant with Squamous Differentiation, Fallopian Tube Endometrioid Adenocarcinoma, Uterine Ligament Endometrioid Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Vaginal Endometrioid Adenocarcinoma, Primary Peritoneal Endometrioid Adenocarcinoma, and Cervical Endometrioid Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.