NCI Definition: An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament. [1]

Endometrioid adenocarcinomas most frequently harbor alterations in PTEN, PIK3CA, ARID1A, PIK3R1, and CTNNB1 [2].

Most Commonly Altered Genes in Endometrioid Adenocarcinoma

PTEN Mutation, PIK3CA Mutation, ARID1fs, CTNNB1 Mutation, and KRAS Mutation are the most common alterations in endometrioid adenocarcinoma [2].

Top Alterations in Endometrioid Adenocarcinoma

Significant Genes in Endometrioid Adenocarcinoma


MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Female Reproductive Endometrioid Carcinoma, Endometrioid Carcinoma of Female Reproductive System, Endometrioid Carcinoma, Endometrioid Carcinoma of the Female Reproductive System
Malignant Female Reproductive System Neoplasm
Endometrioid Adenocarcinoma, Variant with Squamous Differentiation, Primary Peritoneal Endometrioid Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Uterine Ligament Endometrioid Adenocarcinoma, Cervical Endometrioid Adenocarcinoma, and Vaginal Endometrioid Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.