Enteropathy-Associated T-Cell Lymphoma
Associated Genetic Biomarkers
NCI Definition: An uncommon mature T-cell lymphoma of intraepithelial lymphocytes. It usually arises from the small intestine, most commonly the jejunum or ileum. Other less frequent primary anatomic sites include the duodenum, stomach, colon, or outside the gastrointestinal tract. It is seen with increased frequency in regions with a high prevalence of celiac disease. 
There are 10 clinical trials for enteropathy-associated T-cell lymphoma, of which 10 are open and 0 are completed or closed. Of the trials that contain enteropathy-associated T-cell lymphoma as an inclusion criterion, 2 are phase 1 (2 open), 1 is phase 1/phase 2 (1 open), and 7 are phase 2 (7 open).
ALK is the most frequent gene inclusion criterion for enteropathy-associated T-cell lymphoma clinical trials .
Brentuximab vedotin, cyclophosphamide, and doxorubicin are the most common interventions in enteropathy-associated T-cell lymphoma clinical trials.
Significant Genes in Enteropathy-Associated T-Cell Lymphoma
ALK is an inclusion eligibility criterion in 1 clinical trial for enteropathy-associated T-cell lymphoma, of which 1 is open and 0 are closed. Of the trial that contains ALK status and enteropathy-associated T-cell lymphoma as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.