Associated Genetic Biomarkers
NCI Definition: A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO) 
Ependymal tumors most frequently harbor alterations in RELA, C11orf95, CDKN2A, KMT2D, and ARID1B .
C11orf95-RELA Fusion, RELA Fusion, KMT2D Mutation, CDKN2B Loss, and CDKN2A Loss are the most common alterations in ependymal tumor .
There is 1 clinical trial for ependymal tumor, of which 1 is open and 0 are completed or closed. Of the trial that contains ependymal tumor as an inclusion criterion, 1 is phase 1 (1 open).
Ganglioside and H3F3A are the most frequent gene inclusion criteria for ependymal tumor clinical trials .
Gd2-c7r-car-expressing autologous t-lymphocytes, gd2-car-expressing autologous t-lymphocytes, and cyclophosphamide are the most common interventions in ependymal tumor clinical trials.
Significant Genes in Ependymal Tumor
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.