NCI Definition: A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [1]

Epithelial neoplasms most frequently harbor alterations in TP53, KMT2D, RB1, ARID1A, and PIK3CA [2].

Most Commonly Altered Genes in Epithelial Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Exon 8 Mutation, and TP53 Exon 5 Mutation are the most common alterations in epithelial neoplasm [2].

Top Alterations in Epithelial Neoplasm

Disease Details

Neoplasm by Morphology
Papillary Epithelial Neoplasm, Benign Mesonephroma, Glandular Cell Neoplasm, Atypical Ductal Breast Hyperplasia, Ovarian Epithelial Tumor, Squamous Cell Neoplasm, Thymic Epithelial Neoplasm, Choroid Plexus Neoplasm, Adenoma, Endocrine Neoplasm, Acanthoma, Transitional Cell Neoplasm, and Adamantinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.