NCI Definition: A malignant neoplasm arising from mesothelial cells in the pleura. It is characterized by the presence of neoplastic cells with an epithelioid appearance. In the majority of cases, the neoplastic epithelioid cells lack significant cytologic atypia; mitotic figures are infrequently seen. In a minority of cases, the neoplastic cells are poorly differentiated and there is evidence of nuclear atypia and increased mitotic activity. 
Epithelioid mesotheliomas most frequently harbor alterations in BAP1, CDKN2A, NF2, CDKN2B, and SETD2 .
CDKN2A Loss, CDKN2B Loss, BAP1 Mutation, BAP1fs, and NF2 Mutation are the most common alterations in epithelioid mesothelioma .
There are 3 clinical trials for epithelioid mesothelioma, of which 3 are open and 0 are completed or closed. Of the trials that contain epithelioid mesothelioma as an inclusion criterion, 2 are phase 1 (2 open) and 1 is phase 1/phase 2 (1 open).
Bay2287411, hpn536, and lmb-100 are the most common interventions in epithelioid mesothelioma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.