Overview

Esophagogastric carcinomas most frequently harbor alterations in TP53, ERBB2, CDKN2A, KRAS, and ARID1A [2].

Most Commonly Altered Genes in Esophagogastric Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in esophagogastric carcinoma [2].

Top Alterations in Esophagogastric Carcinoma

Significant Genes in Esophagogastric Carcinoma

ERBB2 +

MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Parent(s)
Malignant Esophagogastric Neoplasm
Children
Adenocarcinoma of the Gastroesophageal Junction, Gastric Remnant Adenocarcinoma, Gastric Carcinoma, and Esophageal Carcinoma
OncoTree Name
Esophagogastric Adenocarcinoma
OncoTree Code
EGC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.