Esophagogastric carcinomas most frequently harbor alterations in TP53, CDKN2A, ERBB2, ARID1A, and KRAS [2].

Most Commonly Altered Genes in Esophagogastric Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Exon 8 Mutation, and TP53 Exon 5 Mutation are the most common alterations in esophagogastric carcinoma [2].

Top Alterations in Esophagogastric Carcinoma

Significant Genes in Esophagogastric Carcinoma


Disease Details

Malignant Esophagogastric Neoplasm
Adenocarcinoma of the Gastroesophageal Junction, Gastric Remnant Adenocarcinoma, Esophageal Carcinoma, and Gastric Carcinoma
OncoTree Name
Esophagogastric Adenocarcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.