NCI Definition: An embryonal carcinoma that develops as a primary tumor in an anatomic site other than the testis or ovary. [1]

Extragonadal embryonal carcinomas most frequently harbor alterations in CDKN1B, RAD52, PIK3C2G, KRAS, and KDM5A [2].

Most Commonly Altered Genes in Extragonadal Embryonal Carcinoma

CDKN1B Amplification, RAD52 Amplification, PIK3C2G Amplification, KRAS Amplification, and KDM5A Amplification are the most common alterations in extragonadal embryonal carcinoma [2].

Top Alterations in Extragonadal Embryonal Carcinoma

Disease Details

Primary Extragonadal Embryonal Carcinoma, Extragonadal Primary Embryonal Carcinoma
Malignant Extragonadal Non-Seminomatous Germ Cell Tumor
Central Nervous System Embryonal Carcinoma and Vulvar/Vaginal Embryonal Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.