Overview

NCI Definition: A germ cell tumor arising in an anatomic site other than the testis or ovary (e.g., central nervous system, lung, mediastinum, and retroperitoneum). [1]

Extragonadal germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, TP53, CCND2, and H3F3C [2].

Most Commonly Altered Genes in Extragonadal Germ Cell Tumor

CDKN1B Amplification, KRAS Amplification, H3F3C Amplification, CCND2 Amplification, and TP53 c.217-c.1178 Missense are the most common alterations in extragonadal germ cell tumor [2].

Top Alterations in Extragonadal Germ Cell Tumor

Disease Details

Synonyms
Primary Extragonadal Germ Cell Tumor, Neoplasm of Extragonadal Germ Cell, Neoplasm of the Extragonadal Germ Cell, Tumor of Extragonadal Germ Cell, Tumor of the Extragonadal Germ Cell, Extragonadal germ cell tumors, NOS, Extragonadal Germ Cell Neoplasm, Extragonadal GCT, NOS, Extragonadal Germ Cell Neoplasms
Parent(s)
Germ Cell Tumor
Children
Malignant Extragonadal Germ Cell Tumor, Mature Pericardial Teratoma, Gastric Germ Cell Tumor, Vulvar/Vaginal Germ Cell Tumor, and Central Nervous System Germ Cell Tumor
OncoTree Name
Extra Gonadal Germ Cell Tumor
OncoTree Code
EGCT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.