Extragonadal Germ Cell Tumor
NCI Definition: A germ cell tumor arising in an anatomic site other than the testis or ovary (e.g., central nervous system, lung, mediastinum, and retroperitoneum). 
Extragonadal germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, TP53, CCND2, and H3F3C .
CDKN1B Amplification, KRAS Amplification, H3F3C Amplification, CCND2 Amplification, and TP53 c.217-c.1178 Missense are the most common alterations in extragonadal germ cell tumor .
There is 1 clinical trial for extragonadal germ cell tumor, of which 1 is open and 0 are completed or closed. Of the trial that contains extragonadal germ cell tumor as an inclusion criterion, 1 is phase 2 (1 open).
Nilotinib and paclitaxel are the most common interventions in extragonadal germ cell tumor clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.