Overview

Extrahepatic cholangiocarcinomas most frequently harbor alterations in TP53, KRAS, ARID1A, CDKN2A, and SMAD4 [2].

Most Commonly Altered Genes in Extrahepatic Cholangiocarcinoma

TP53 Mutation, KRAS Mutation (somatic), KRAS Mutation (germline), KRAS Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in extrahepatic cholangiocarcinoma [2].

Top Alterations in Extrahepatic Cholangiocarcinoma

Significant Genes in Extrahepatic Cholangiocarcinoma

ERBB2 +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

Disease Details

Parent(s)
Cholangiocarcinoma
OncoTree Name
Extrahepatic Cholangiocarcinoma
OncoTree Code
EHCH

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.