Extramammary Paget Disease
NCI Definition: A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It may affect the anus, penis, scrotum, and vulva. 
Extramammary Paget diseases most frequently harbor alterations in PIK3CA, ERBB2, KMT2C, and TP53 .
PIK3CA Mutation, ERBB2 Mutation, TP53 Mutation, TP53 Missense, and KMT2C Mutation are the most common alterations in extramammary Paget disease .
There is 1 clinical trial for extramammary Paget disease, of which 1 is open and 0 are completed or closed. Of the trial that contains extramammary Paget disease as an inclusion criterion, 1 is phase 2 (1 open).
Ipilimumab and nivolumab are the most common interventions in extramammary Paget disease clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.