Associated Genetic Biomarkers

Overview

NCI Definition: An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001) [1]

Significant Genes in Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

ALK +

BCL2 +

BCL6 +

IRF4 +

MYC +

Disease Details

Synonyms
MALT-lymphoma, MALToma, MALT Lymphoma, Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue, mucosa-associated lymphoid tissue lymphoma, Immunocytoma, Extranodal marginla zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma), Mucosa-Associated Lymphoid Tissue Lymphoma
Parent(s)
Marginal Zone Lymphoma
Children
Thymic Mucosa-Associated Lymphoid Tissue Lymphoma and Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
OncoTree Name
Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)
OncoTree Code
EMALT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.