NCI Definition: A conventional osteosarcoma characterized by the presence of spindle shaped cells. 
Fibroblastic osteosarcomas most frequently harbor alterations in POLE, NCOR1, FLCN, and CDKN2A .
POLE V240G, POLE Mutation, NCOR1 Loss, FLCN Loss, and CDKN2A Mutation are the most common alterations in fibroblastic osteosarcoma .
There is 1 clinical trial for fibroblastic osteosarcoma, of which 1 is open and 0 are completed or closed. Of the trial that contains fibroblastic osteosarcoma as an inclusion criterion, 1 is phase 1 (1 open).
Bo-112, nivolumab, and radiation therapy are the most common interventions in fibroblastic osteosarcoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.