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Fibroblastic Osteosarcoma

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Overview

NCI Definition: A conventional osteosarcoma characterized by the presence of spindle shaped cells. [1]

Fibroblastic osteosarcomas most frequently harbor alterations in POLE, NCOR1, FLCN, and CDKN2A [2].

Most Commonly Altered Genes in Fibroblastic Osteosarcoma

POLE V240G, POLE Mutation, NCOR1 Loss, FLCN Loss, and CDKN2A Mutation are the most common alterations in fibroblastic osteosarcoma [2].

Top Alterations in Fibroblastic Osteosarcoma

Clinical Trials

View Clinical Trials for Fibroblastic Osteosarcoma

Disease Details

Synonyms
Fibrosarcomatous Osteogenic Sarcoma, Fibrosarcomatous Osteosarcoma, Fibroblastic Osteogenic Sarcoma
Parent(s)
Conventional Osteosarcoma
OncoTree Name
Fibroblastic Osteosarcoma
OncoTree Code
FIOS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.