Diseases /

Fibrolamellar Carcinoma

Back to Diseases List
Associated Genetic Biomarkers

Overview

NCI Definition: A distinctive type of liver cell carcinoma that arises in non-cirrhotic livers and is seen predominantly in young patients. The tumor cells are polygonal and deeply eosinophilic, and are embedded in a fibrous stroma. The prognosis is similar to classical hepatocellular carcinoma that arises in non-cirrhotic livers, and better than hepatocellular carcinoma that arises in cirrhotic livers. [1]

Clinical Trials

View Clinical Trials for Fibrolamellar Carcinoma

Significant Genes in Fibrolamellar Carcinoma

DNAJB1 +

PRKACA +

Disease Details

Synonyms
Liver Cell Fibrolamellar Carcinoma, Polygonal Cell Type Hepatocellular Carcinoma with Fibrous Stroma, Fibrolamellar Hepatocellular Carcinoma, Fibrolamellar Carcinoma of Liver Cells, Fibrolamellar Carcinoma of the Liver Cells, Hepatocellular Fibrolamellar Carcinoma, FLC, Oncocytic Hepatocellular Tumor
Parent(s)
Hepatocellular Carcinoma
OncoTree Name
Fibrolamellar Carcinoma
OncoTree Code
FLC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.