Overview

NCI Definition: An adenocarcinoma arising from the gallbladder. It is the most common malignant tumor of the gallbladder and it is usually well to moderately differentiated. The incidence is higher in patients with gallstones than in patients without gallstones. Signs and symptoms usually present late in the course of the disease and are reminiscent of those of chronic cholecystitis including right upper quadrant pain. Histologic variants include adenocarcinoma of the intestinal type, clear cell adenocarcinoma, mucinous adenocarcinoma, papillary adenocarcinoma, and signet ring adenocarcinoma. [1]

Gallbladder adenocarcinomas most frequently harbor alterations in TP53, CDKN2A, SMAD4, ERBB2, and ARID1A [2].

Most Commonly Altered Genes in Gallbladder Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 7 Mutation, and TP53 Exon 8 Mutation are the most common alterations in gallbladder adenocarcinoma [2].

Top Alterations in Gallbladder Adenocarcinoma

Significant Genes in Gallbladder Adenocarcinoma

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Synonyms
Adenocarcinoma of the Gallbladder, Adenocarcinoma of Gallbladder
Parent(s)
Adenocarcinoma
Children
Gallbladder Signet Ring Cell Carcinoma, Gallbladder Papillary Neoplasm with an Associated Invasive Carcinoma, and Gallbladder Mucinous Adenocarcinoma
OncoTree Name
Gallbladder Adenocarcinoma, NOS
OncoTree Code
GBAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.