Diseases /
Gallbladder Carcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A malignant tumor arising from the epithelium of the gallbladder. It is usually associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur. [1]
Gallbladder carcinomas most frequently harbor alterations in TP53, CDKN2A, SMAD4, ARID1A, and CDKN2B [2].
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 7 Mutation, and SMAD4 Mutation are the most common alterations in gallbladder carcinoma [2].
Clinical Trials
Significant Genes in Gallbladder Carcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.