Overview

NCI Definition: A malignant tumor arising from the epithelium of the gallbladder. It is usually associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur. [1]

Gallbladder carcinomas most frequently harbor alterations in TP53, SMAD4, CDKN2A, ARID1A, and CDKN2B [2].

Most Commonly Altered Genes in Gallbladder Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, SMAD4 Mutation, and ARID1A Mutation are the most common alterations in gallbladder carcinoma [2].

Top Alterations in Gallbladder Carcinoma

Significant Genes in Gallbladder Carcinoma

AKT1 +

ALK +

ATM +

BRAF +

BRCA1 +

BRCA2 +

CCND1 +

CDK4 +

CDK6 +

CDKN2A +

CSF1R +

EGFR +

EPCAM +

ERBB2 +

ERBB3 +

EXO1 +

FGFR1 +

FGFR2 +

FGFR3 +

FLT1 +

FLT3 +

FLT4 +

IDH1 +

IDH2 +

KDR +

KIT +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MST1R +

MTOR +

NRG1 +

PALB2 +

PCNA +

PDGFRA +

PDGFRB +

PIK3CA +

PMS1 +

PMS2 +

POLD1 +

POLE +

RAF1 +

RET +

RFC1 +

RFC2 +

RFC3 +

RFC4 +

RFC5 +

ROS1 +

RPA1 +

RPA2 +

RPA3 +

RPA4 +

SSBP1 +

TSC1 +

TSC2 +

VHL +

Disease Details

Synonyms
Gall bladder carcinoma (adeno), Gallbladder Cancer, Carcinoma of Gallbladder, Cancer of the Gallbladder, Gall bladder carcinoma (adenocarcinoma), Cancer of Gallbladder, Carcinoma of the Gallbladder
Parent(s)
Malignant Gallbladder Neoplasm
Children
Gallbladder Adenocarcinoma, Gallbladder Adenosquamous Carcinoma, Gallbladder Small Cell Neuroendocrine Carcinoma, and Gallbladder Squamous Cell Carcinoma
OncoTree Name
Gallbladder Cancer
OncoTree Code
GBC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.