Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma that arises from the stomach and is characterized by the presence of malignant cells with glandular and squamous differentiation. [1]

Gastric adenosquamous carcinomas most frequently harbor alterations in ZNF708, TP53, SMARCA4, RAD21, and PRDM1 [2].

Most Commonly Altered Genes in Gastric Adenosquamous Carcinoma

ZNF708 E451D, TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, and TP53 L194F are the most common alterations in gastric adenosquamous carcinoma [2].

Top Alterations in Gastric Adenosquamous Carcinoma

Disease Details

Synonyms
Adenosquamous Carcinoma of the Stomach, Adenosquamous Carcinoma of Stomach
Parent(s)
Gastric Carcinoma
OncoTree Name
Adenosquamous Carcinoma of the Stomach
OncoTree Code
STAS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.