Associated Genetic Biomarkers


NCI Definition: An adenocarcinoma arising from the stomach. Microscopically, it is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma. Many cells contain mucin droplets, producing a signet-ring configuration. [1]

Gastric diffuse adenocarcinomas most frequently harbor alterations in TP53, CDH1, ARID1A, CDKN2A, and KRAS [2].

Most Commonly Altered Genes in Gastric Diffuse Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CDH1 Mutation, and TP53 Exon 7 Mutation are the most common alterations in gastric diffuse adenocarcinoma [2].

Top Alterations in Gastric Diffuse Adenocarcinoma

Significant Genes in Gastric Diffuse Adenocarcinoma

CDH1 +

Disease Details

Diffuse Gastric Adenocarcinoma, Diffuse Stomach Adenocarcinoma, Adenocarcinoma of the Linitis Plastica Type, Diffuse Adenocarcinoma of Stomach, Diffuse Adenocarcinoma of the Stomach, Adenocarcinoma of Linitis Plastica Type
Gastric Adenocarcinoma
Mucinous Gastric Adenocarcinoma, Signet Ring Cell Gastric Adenocarcinoma, and Linitis Plastica
OncoTree Name
Diffuse Type Stomach Adenocarcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.