Overview

NCI Definition: An adenocarcinoma arising from the stomach. Microscopically, it is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma. Many cells contain mucin droplets, producing a signet-ring configuration. [1]

Gastric diffuse adenocarcinomas most frequently harbor alterations in TP53, CDH1, ARID1A, CDKN2A, and KRAS [2].

Most Commonly Altered Genes in Gastric Diffuse Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CDH1 Mutation, and TP53 Exon 7 Mutation are the most common alterations in gastric diffuse adenocarcinoma [2].

Top Alterations in Gastric Diffuse Adenocarcinoma

Significant Genes in Gastric Diffuse Adenocarcinoma

ERBB2 +

Disease Details

Synonyms
Diffuse Stomach Adenocarcinoma, Adenocarcinoma of the Linitis Plastica Type, Adenocarcinoma of Linitis Plastica Type, Diffuse Gastric Adenocarcinoma, Diffuse Adenocarcinoma of Stomach, Diffuse Adenocarcinoma of the Stomach
Parent(s)
Gastric Adenocarcinoma
Children
Linitis Plastica, Signet Ring Cell Gastric Adenocarcinoma, and Mucinous Gastric Adenocarcinoma
OncoTree Name
Diffuse Type Stomach Adenocarcinoma
OncoTree Code
DSTAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.