Overview

NCI Definition: An adenocarcinoma arising from the stomach. Microscopically, it is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma. Many cells contain mucin droplets, producing a signet-ring configuration. [1]

Gastric diffuse adenocarcinomas most frequently harbor alterations in TP53, CDH1, ARID1A, CDKN2A, and KRAS [2].

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CDH1 Mutation, and TP53 Exon 7 Mutation are the most common alterations in gastric diffuse adenocarcinoma [2].

Significant Genes in Gastric Diffuse Adenocarcinoma

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.