NCI Definition: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [1]

Gastric neuroendocrine carcinomas most frequently harbor alterations in TP53, RB1, ATM, VHL, and TSHR [2].

Most Commonly Altered Genes in Gastric Neuroendocrine Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RB1 Mutation, and ATM Mutation are the most common alterations in gastric neuroendocrine carcinoma [2].

Top Alterations in Gastric Neuroendocrine Carcinoma

Disease Details

Gastric NEC, Gastric (Stomach) Neuroendocrine Cancer
Neuroendocrine Carcinoma
Gastric Small Cell Neuroendocrine Carcinoma
OncoTree Name
High-Grade Neuroendocrine Carcinoma of the Stomach
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.