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Gastric Neuroendocrine Tumor

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Associated Genetic Biomarkers

Overview

NCI Definition: A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the stomach. [1]

Gastric neuroendocrine tumors most frequently harbor alterations in TP53, ARID1A, TSHR, SETD2, and RB1 [2].

Most Commonly Altered Genes in Gastric Neuroendocrine Tumor

ARID1fs, TSHR Mutation, TSHR D276E, TP53fs, and TP53 c.217-c.1178 Missense are the most common alterations in gastric neuroendocrine tumor [2].

Top Alterations in Gastric Neuroendocrine Tumor

Biomarker-Directed Therapies

View Therapies for Gastric Neuroendocrine Tumor

Clinical Trials

View Clinical Trials for Gastric Neuroendocrine Tumor

Disease Details

Synonyms
Gastric Well Differentiated Endocrine Tumor/Carcinoma, Gastric Well Differentiated Endocrine Tumor, Gastric NET
Parent(s)
Gastrointestinal Neuroendocrine Tumors
Children
Gastric Gastrin-Producing Neuroendocrine Tumor
OncoTree Name
Well-Differentiated Neuroendocrine Tumors of the Stomach
OncoTree Code
SWDNET

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.