Gastrointestinal Neuroendocrine Tumors
Associated Genetic Biomarkers
NCI Definition: A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas. 
Gastrointestinal neuroendocrine tumorss most frequently harbor alterations in TP53, MEN1, KMT2A, KRAS, and APC .
TP53 Mutation, MEN1 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, and TP53 c.1-c.137 Missense are the most common alterations in gastrointestinal neuroendocrine tumors .
There are 4 clinical trials for gastrointestinal neuroendocrine tumors, of which 4 are open and 0 are completed or closed. Of the trials that contain gastrointestinal neuroendocrine tumors as an inclusion criterion, 1 is phase 1 (1 open), 2 are phase 2 (2 open), and 1 is phase 3 (1 open).
Incomplete freund's adjuvant, octreotide acetate, and svn53-67/m57-klh peptide vaccine are the most common interventions in gastrointestinal neuroendocrine tumors clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.