Gestational Trophoblastic Tumor
NCI Definition: A diverse group of pregnancy-related tumors characterized by excessive proliferation of trophoblasts. Representative examples include hydatidiform mole, gestational choriocarcinoma, and placental site trophoblastic tumor. 
Gestational trophoblastic tumors most frequently harbor alterations in TP53, SPEN, KMT2D, KEAP1, and SMAD4 .
TP53 Mutation, KEAP1 Mutation, TP53 c.217-c.1178 Missense, TP53 Nonsense, and TP53 Missense are the most common alterations in gestational trophoblastic tumor .
There are 2 clinical trials for gestational trophoblastic tumor, of which 2 are open and 0 are completed or closed. Of the trials that contain gestational trophoblastic tumor as an inclusion criterion, 2 are phase 2 (2 open).
Ipilimumab, nilotinib, and nivolumab are the most common interventions in gestational trophoblastic tumor clinical trials.
Significant Genes in Gestational Trophoblastic Tumor
CD274 is an inclusion eligibility criterion in 1 clinical trial for gestational trophoblastic tumor, of which 1 is open and 0 are closed. Of the trial that contains CD274 status and gestational trophoblastic tumor as inclusion criteria, 1 is phase 2 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.