NCI Definition: A diverse group of pregnancy-related tumors characterized by excessive proliferation of trophoblasts. Representative examples include hydatidiform mole, gestational choriocarcinoma, and placental site trophoblastic tumor. [1]

Gestational trophoblastic tumors most frequently harbor alterations in TP53, SPEN, KMT2D, KEAP1, and SMAD4 [2].

Most Commonly Altered Genes in Gestational Trophoblastic Tumor

TP53 Mutation, KEAP1 Mutation, TP53 c.217-c.1178 Missense, TP53 Nonsense, and TP53 Missense are the most common alterations in gestational trophoblastic tumor [2].

Top Alterations in Gestational Trophoblastic Tumor

Significant Genes in Gestational Trophoblastic Tumor

CD274 +

Disease Details

gestational trophoblastic disease, Gestational Trophoblastic Disease, GTT, gestational trophoblastic neoplasia, Gestational trophoblastic disease, gestational trophoblastic tumor
Trophoblastic Neoplasm
Epithelioid Trophoblastic Tumor, Gestational Choriocarcinoma, and Placental-Site Gestational Trophoblastic Tumor
OncoTree Name
Gestational Trophoblastic Disease
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.