Overview

NCI Definition: A glioblastoma that arises de novo. It is more commonly seen in older patients. Mutations in IDH1 or IDH2 genes are not present. [1]

Glioblastoma, IDH-wildtypes most frequently harbor alterations in TP53, PTEN, NF1, RB1, and CDKN2A [2].

Most Commonly Altered Genes in Glioblastoma, IDH-Wildtype

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PTEN Mutation, and CDKN2A Loss are the most common alterations in glioblastoma, IDH-wildtype [2].

Top Alterations in Glioblastoma, IDH-Wildtype

Significant Genes in Glioblastoma, IDH-Wildtype

EGFR +

TERT +

Disease Details

Parent(s)
Glioblastoma
Children
Giant Cell Glioblastoma and Gliosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.