Overview

NCI Definition: A rare histological variant of glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation (WHO). [1]

Gliosarcomas most frequently harbor alterations in TP53, PTEN, NF1, CDKN2A, and RB1 [2].

Most Commonly Altered Genes in Gliosarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PTEN Mutation, and PTEN Nonsense are the most common alterations in gliosarcoma [2].

Top Alterations in Gliosarcoma

Significant Genes in Gliosarcoma

ATRX +

EGFR +

H3F3A +

MET +

TERT +

TP53 +

Disease Details

Synonyms
Glioblastoma with a Sarcomatous Component
Parent(s)
Glioblastoma, IDH-Wildtype
OncoTree Name
Gliosarcoma
OncoTree Code
GSARC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.