Overview

NCI Definition: An atypical meningioma which may recur in approximately 29-40% of the cases. This category includes the atypical meningioma, chordoid meningioma, and clear cell meningioma. [1]

Grade II meningiomas most frequently harbor alterations in NF2, CDKN2A, SMO, ROS1, and PTEN [2].

Most Commonly Altered Genes in Grade II Meningioma

NF2fs, NF2 Mutation, NF2 Nonsense, CDKN2A Loss, and SMO Mutation are the most common alterations in grade II meningioma [2].

Top Alterations in Grade II Meningioma

Disease Details

Synonyms
Meningioma, WHO grade II
Parent(s)
Meningioma
Children
Chordoid Meningioma, Atypical Meningioma, and Clear Cell Meningioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.