NCI Definition: An atypical meningioma which may recur in approximately 29-40% of the cases. This category includes the atypical meningioma, chordoid meningioma, and clear cell meningioma. [1]

Grade II meningiomas most frequently harbor alterations in NF2, CDKN2A, SMO, ROS1, and PTEN [2].

Most Commonly Altered Genes in Grade II Meningioma

NF2fs, NF2 Mutation, NF2 Nonsense, CDKN2A Loss, and SMO Mutation are the most common alterations in grade II meningioma [2].

Top Alterations in Grade II Meningioma

Disease Details

Meningioma, WHO grade II
Clear Cell Meningioma, Chordoid Meningioma, and Atypical Meningioma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.