Overview

Head and neck neuroendocrine carcinomas most frequently harbor alterations in TP53, RB1, KMT2D, HRAS, and SMARCA4 [2].

Most Commonly Altered Genes in Head and Neck Neuroendocrine Carcinoma

TP53 Mutation, KMT2D Mutation, RB1 Nonsense, RB1 Mutation, and HRAS Mutation are the most common alterations in head and neck neuroendocrine carcinoma [2].

Top Alterations in Head and Neck Neuroendocrine Carcinoma

Disease Details

Parent(s)
Neuroendocrine Carcinoma
Children
Salivary Gland Small Cell Carcinoma, Nasal Cavity and Paranasal Sinus Neuroendocrine Carcinoma, and Laryngeal Small Cell Carcinoma
OncoTree Name
Head and Neck Neuroendocrine Carcinoma
OncoTree Code
HNNE

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.