Overview

Head and neck squamous cell carcinoma of unknown primarys most frequently harbor alterations in TP53, CDKN2A, PIK3CA, NOTCH1, and KMT2D [2].

Most Commonly Altered Genes in Head and Neck Squamous Cell Carcinoma of Unknown Primary

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Nonsense, and KEAP1 Mutation are the most common alterations in head and neck squamous cell carcinoma of unknown primary [2].

Top Alterations in Head and Neck Squamous Cell Carcinoma of Unknown Primary

Disease Details

Parent(s)
Head and Neck Squamous Cell Carcinoma
OncoTree Name
Head and Neck Squamous Cell Carcinoma of Unknown Primary
OncoTree Code
HNSCUP

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.