Overview

NCI Definition: A neoplastic or non-neoplastic disorder that affects the production and proliferation of the hematopoietic cells including lymphoid cells, the synthesis of hemoglobin, and/or the mechanisms of coagulation. [1]

Hematologic and lymphocytic disorders most frequently harbor alterations in KMT2D, TP53, CREBBP, BCL2, and TET2 [2].

Most Commonly Altered Genes in Hematologic and Lymphocytic Disorder

TP53 Mutation, CREBBP Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KMT2D Mutation are the most common alterations in hematologic and lymphocytic disorder [2].

Top Alterations in Hematologic and Lymphocytic Disorder

Significant Genes in Hematologic and Lymphocytic Disorder

AKT1 +

AKT2 +

AKT3 +

CRKL +

MTOR +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RICTOR +

RPTOR +

TSC1 +

TSC2 +

Disease Details

Parent(s)
Hematopoietic and Lymphoid System Disorder
Children
Lymphoproliferative Disorder, Leukocyte Disease, and Non-Neoplastic Hematologic and Lymphocytic Disorder

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.