NCI Definition: A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes. [1]

Hematopoietic and lymphoid cell neoplasms most frequently harbor alterations in TP53, TET2, DNMT3A, ASXL1, and JAK2 [2].

Most Commonly Altered Genes in Hematopoietic and Lymphoid Cell Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, DNMT3A Mutation, and TET2 Mutation are the most common alterations in hematopoietic and lymphoid cell neoplasm [2].

Top Alterations in Hematopoietic and Lymphoid Cell Neoplasm

Disease Details

Hematologic Neoplasm, Hematopoietic Tumor, Hematological Tumor, Hematopoietic Cancer, Hematopoietic, Including Myeloma, Hematopoietic Cell Tumor, Hematological Neoplasm, Hematopoietic Neoplasm, Hematopoietic and Lymphoid Neoplasms, Malignant Hematopoietic Neoplasm, Hematopoietic malignancy, NOS, Malignant Hematologic Neoplasm, Hematologic Malignancy, Hematologic Cancer, Hematopoietic Neoplasms including Lymphomas
Hematopoietic and Lymphoid System Neoplasm
Histiocytic and Dendritic Cell Neoplasm, Refractory Hematologic Malignancy, Lymphocytic Neoplasm, Central Nervous System Hematopoietic Neoplasm, and Myeloid Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.