NCI Definition: Any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs. [1]

Hematopoietic and lymphoid system disorders most frequently harbor alterations in TP53, TET2, DNMT3A, ASXL1, and JAK2 [2].

Most Commonly Altered Genes in Hematopoietic and Lymphoid System Disorder

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, DNMT3A Mutation, and TET2 Mutation are the most common alterations in hematopoietic and lymphoid system disorder [2].

Top Alterations in Hematopoietic and Lymphoid System Disorder

Disease Details

Disease or Disorder
Hematologic and Lymphocytic Disorder, Hematopoietic and Lymphoid System Neoplasm, Atypical Myeloid Disorder, Hematopoietic System Disease, and Lymphatic System Disease


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.