NCI Definition: A large B-cell lymphoma characterized by the presence of a diffuse proliferation of large, atypical HHV8-positive neoplastic lymphocytes. It usually arises in association with HHV8-positive multicentric Castleman disease. [1]

Significant Genes in HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified


BCL2 +

BCL6 +


Disease Details

Human Herpesvirus 8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, HHV8-Positive Diffuse Large B-Cell Lymphoma, NOS, HHV8-Positive DLBCL, NOS, HHV8 Positive DLBCL, NOS
Diffuse Large B-Cell Lymphoma
OncoTree Name
HHV8 Positive DLBCL, NOS
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.