High grade astrocytic tumors most frequently harbor alterations in TP53, PTEN, CDKN2A, EGFR, and CDKN2B [2].

Most Commonly Altered Genes in High Grade Astrocytic Tumor

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, CDKN2A Loss, and CDKN2B Loss are the most common alterations in high grade astrocytic tumor [2].

Top Alterations in High Grade Astrocytic Tumor

Disease Details

Malignant Glioma
Glioblastoma and Anaplastic Astrocytoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.