High Grade Cervical Intraepithelial Neoplasia
Associated Genetic Biomarkers
NCI Definition: Squamous or glandular cervical intraepithelial neoplasia characterized by the presence of moderate or severe dysplastic changes. 
There are 9 clinical trials for high grade cervical intraepithelial neoplasia, of which 6 are open and 3 are completed or closed. Of the trials that contain high grade cervical intraepithelial neoplasia as an inclusion criterion, 1 is early phase 1 (1 open), 3 are phase 1 (1 open), 3 are phase 2 (3 open), and 2 are phase 3 (1 open).
CDKN2A and HPV are the most frequent gene inclusion criteria for high grade cervical intraepithelial neoplasia clinical trials .
Imiquimod, placebo, and electroporation are the most common interventions in high grade cervical intraepithelial neoplasia clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.