Overview

NCI Definition: A rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures. [1]

High grade fallopian tube serous adenocarcinomas most frequently harbor alterations in TP53, NOTCH3, CCNE1, BRD4, and SMARCA4 [2].

Most Commonly Altered Genes in High Grade Fallopian Tube Serous Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 8 Mutation, and TP53fs are the most common alterations in high grade fallopian tube serous adenocarcinoma [2].

Top Alterations in High Grade Fallopian Tube Serous Adenocarcinoma

Significant Genes in High Grade Fallopian Tube Serous Adenocarcinoma

ATM +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

FANCL +

PALB2 +

PIK3CA +

POLE +

PPP2R2A +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

TP53 +

Disease Details

Synonyms
High-grade Serous Carcinoma Favor Tubal Primary, High-grade serous carcinoma, favor tubal primary
Parent(s)
Fallopian Tube Serous Adenocarcinoma
OncoTree Name
High-Grade Serous Fallopian Tube Cancer
OncoTree Code
HGSFT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.