High-grade glioma, NOSs most frequently harbor alterations in TP53, CDKN2A, CDKN2B, ATRX, and IDH1 [2].

Most Commonly Altered Genes in High-Grade Glioma, NOS

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in high-grade glioma, NOS [2].

Top Alterations in High-Grade Glioma, NOS

Disease Details

Malignant Glioma
OncoTree Name
High-Grade Glioma, NOS
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.