Overview

High-grade glioma, NOSs most frequently harbor alterations in TP53, CDKN2A, CDKN2B, ATRX, and NF1 [2].

Most Commonly Altered Genes in High-Grade Glioma, NOS

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CDKN2A Loss, and CDKN2B Loss are the most common alterations in high-grade glioma, NOS [2].

Top Alterations in High-Grade Glioma, NOS

Significant Genes in High-Grade Glioma, NOS

APC +

CDK6 +

CTDNEP1 +

CTNNB1 +

DDX3X +

GLI2 +

H3F3A +

IDH1 +

IDH2 +

KDM6A +

KMT2C +

KMT2D +

LRP1B +

MDM4 +

MYC +

MYCL +

MYCN +

OTX2 +

PPM1D +

PTCH1 +

PTEN +

PVT1 +

RELA +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SUFU +

TERT +

TP53 +

YAP1 +

ZMYM3 +

Disease Details

Synonyms
High-Grade Glioma, High Grade Glioma
Parent(s)
Malignant Glioma
OncoTree Name
High-Grade Glioma, NOS
OncoTree Code
HGGNOS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.