Overview

NCI Definition: A lymphoma, previously known as Hodgkin's disease, characterized by the presence of large tumor cells in an abundant admixture of nonneoplastic cells. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. [1]

Hodgkin lymphomas most frequently harbor alterations in TP53, SOCS1, TNFAIP3, B2M, and KMT2D [2].

Most Commonly Altered Genes in Hodgkin Lymphoma

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, SOCS1fs, and XPO1 Mutation are the most common alterations in hodgkin lymphoma [2].

Top Alterations in Hodgkin Lymphoma

Significant Genes in Hodgkin Lymphoma

ABL1 +

AFF1 +

ALK +

ASXL1 +

BCL2 +

BCL6 +

BCR +

BRAF +

CBFA2T3 +

CBFB +

CCND1 +

CREBBP +

DEK +

DNMT3A +

ELL +

ETV6 +

FGFR3 +

FLT3 +

GLIS2 +

HIP1 +

HOXA9 +

IGH +

IKZF1 +

KAT6A +

KDM5A +

KIT +

KMT2A +

MAF +

MAFB +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MYC +

MYCN +

MYH11 +

NOTCH1 +

NPM1 +

NRIP3 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

PDGFRB +

PHF6 +

PRDM16 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TET2 +

TP53 +

WHSC1 +

WT1 +

Disease Details

Synonyms
Hodgkin disease, Hodgkin lymphoma, NOS, Hodgkins, Hodgkin's Disease, Hodgkin's Lymphoma, HL, Lymph node lymphoma Hodgkins disease
Parent(s)
Lymphoma
Children
Classical Hodgkin Lymphoma, Mediastinal Hodgkin Lymphoma, Classic Hodgkin Lymphoma Type Post-Transplant Lymphoproliferative Disorder, and Nodular Lymphocyte-Predominant Hodgkin Lymphoma
OncoTree Name
Hodgkin Lymphoma
OncoTree Code
HL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.