Diseases /
Hodgkin Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A lymphoma, previously known as Hodgkin's disease, characterized by the presence of large tumor cells in an abundant admixture of nonneoplastic cells. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. [1]
Hodgkin lymphomas most frequently harbor alterations in TP53, SOCS1, TNFAIP3, B2M, and KMT2D [2].
TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, SOCS1fs, and XPO1 Mutation are the most common alterations in hodgkin lymphoma [2].
Clinical Trials
Significant Genes in Hodgkin Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.