Overview

NCI Definition: A lymphoma, previously known as Hodgkin's disease, characterized by the presence of large tumor cells in an abundant admixture of nonneoplastic cells. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. [1]

Hodgkin lymphomas most frequently harbor alterations in SOCS1, TP53, TNFAIP3, KMT2D, and CUX1 [2].

Most Commonly Altered Genes in Hodgkin Lymphoma

TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in hodgkin lymphoma [2].

Top Alterations in Hodgkin Lymphoma

Significant Genes in Hodgkin Lymphoma

ABL1 +

AFF1 +

ALK +

BCL2 +

BCL6 +

BCR +

BRAF +

CBFA2T3 +

CBFB +

CREBBP +

DEK +

ELL +

ERG +

ETV6 +

FLT3 +

FUS +

GLIS2 +

HOXA9 +

IKZF1 +

KAT6A +

KDM5A +

KIT +

KMT2A +

MECOM +

MLF1 +

MLH1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MSH2 +

MSH6 +

MYC +

MYH11 +

NOTCH1 +

NPM1 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

PMS2 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

WT1 +

Disease Details

Synonyms
Hodgkin's Lymphoma, Hodgkin's Disease, Hodgkin disease, Hodgkins, HL, Hodgkin lymphoma, NOS
Parent(s)
Lymphoma
Children
Mediastinal Hodgkin Lymphoma, Classical Hodgkin Lymphoma, Nodular Lymphocyte-Predominant Hodgkin Lymphoma, and Classic Hodgkin Lymphoma Type Post-Transplant Lymphoproliferative Disorder
OncoTree Name
Hodgkin Lymphoma
OncoTree Code
HL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.