Overview

NCI Definition: A lymphoma, previously known as Hodgkin's disease, characterized by the presence of large tumor cells in an abundant admixture of nonneoplastic cells. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes. [1]

Hodgkin lymphomas most frequently harbor alterations in TP53, SOCS1, TNFAIP3, B2M, and KMT2D [2].

Most Commonly Altered Genes in Hodgkin Lymphoma

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, SOCS1fs, and XPO1 Mutation are the most common alterations in hodgkin lymphoma [2].

Top Alterations in Hodgkin Lymphoma

Significant Genes in Hodgkin Lymphoma

ABL1 +

AFF1 +

ALK +

ASXL1 +

BCL2 +

BCL6 +

BCR +

BRAF +

CBFA2T3 +

CBFB +

CCND1 +

CREBBP +

DEK +

DNMT3A +

ELL +

ETV6 +

FGFR3 +

FLT3 +

GLIS2 +

HIP1 +

HOXA9 +

IGH +

IKZF1 +

KAT6A +

KDM5A +

KIT +

KMT2A +

MAF +

MAFB +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MYC +

MYCN +

MYH11 +

NOTCH1 +

NPM1 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

PDGFRB +

PHF6 +

PRDM16 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TET2 +

TP53 +

WHSC1 +

WT1 +

Disease Details

Synonyms
Hodgkin disease, HL, Hodgkins, Hodgkin's Disease, Hodgkin's Lymphoma, Hodgkin lymphoma, NOS, Lymph node lymphoma Hodgkins disease
Parent(s)
Lymphoma
Children
Classic Hodgkin Lymphoma Type Post-Transplant Lymphoproliferative Disorder, Nodular Lymphocyte-Predominant Hodgkin Lymphoma, Classical Hodgkin Lymphoma, and Mediastinal Hodgkin Lymphoma
OncoTree Name
Hodgkin Lymphoma
OncoTree Code
HL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.