Immature Ovarian Teratoma
NCI Definition: A malignant germ cell tumor arising from the ovary. It usually affects females in their first two decades of life. It contains variable amounts of immature embryonal tissues. Based on the amount of immature neuroepithelial component, immature teratomas are graded from 1 to 3. The stage and grade of the tumor and the grade of the metastatic tumor are the important factors that predict prognosis. The use of cisplatin-based combination chemotherapy has significantly improved the survival rates of the patients. 
Immature ovarian teratomas most frequently harbor alterations in ZFHX3, TP53, SQSTM1, SH2B3, and PLCG2 .
ZFHX3 Q1741delinsHK, TP53 c.217-c.1178 Missense, TP53 Y234C, TP53 Y163H, and TP53 Mutation are the most common alterations in immature ovarian teratoma .
There is 1 clinical trial for immature ovarian teratoma, of which 1 is open and 0 are completed or closed. Of the trial that contains immature ovarian teratoma as an inclusion criterion, 1 is phase 3 (1 open).
Observation is the most common intervention in immature ovarian teratoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.