Overview

NCI Definition: A malignant germ cell tumor arising from the ovary. It usually affects females in their first two decades of life. It contains variable amounts of immature embryonal tissues. Based on the amount of immature neuroepithelial component, immature teratomas are graded from 1 to 3. The stage and grade of the tumor and the grade of the metastatic tumor are the important factors that predict prognosis. The use of cisplatin-based combination chemotherapy has significantly improved the survival rates of the patients. [1]

Immature ovarian teratomas most frequently harbor alterations in ZFHX3, TP53, SQSTM1, SH2B3, and PLCG2 [2].

Most Commonly Altered Genes in Immature Ovarian Teratoma

ZFHX3 Q1741delinsHK, TP53 c.217-c.1178 Missense, TP53 Y234C, TP53 Y163H, and TP53 Mutation are the most common alterations in immature ovarian teratoma [2].

Top Alterations in Immature Ovarian Teratoma

Disease Details

Synonyms
Immature Germ Cell Teratoma of the Ovary, Malignant Germ Cell Teratoma of the Ovary, Ovarian Immature Germ Cell Teratoma, Immature Germ Cell Teratoma of Ovary, Ovarian Germ Cell Immature Teratoma, Immature Teratoma of Ovary, Malignant Ovarian Teratoma, Malignant Teratoma of the Ovary, Immature Teratoma of the Ovary, Malignant Teratoma of Ovary, Malignant Ovarian Germ Cell Teratoma, Ovarian Immature Teratoma, Malignant Germ Cell Teratoma of Ovary
Parent(s)
Ovarian Biphasic or Triphasic Teratoma
Children
Childhood Ovarian Immature Teratoma
OncoTree Name
Immature Teratoma
OncoTree Code
OIMT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.