Overview

NCI Definition: A non-Hodgkin lymphoma with an indolent clinical course. Representative examples include grade 1 and grade 2 follicular lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma. [1]

Indolent non-hodgkin lymphomas most frequently harbor alterations in KMT2D, TNFAIP3, ARID1A, TP53, and MYD88 [2].

Most Commonly Altered Genes in Indolent Non-Hodgkin Lymphoma

KMT2D Mutation, MYD88 Mutation, MYD88 L265P, MYD88 Exon 5 Mutation, and FAT1 Mutation are the most common alterations in indolent non-hodgkin lymphoma [2].

Top Alterations in Indolent Non-Hodgkin Lymphoma

Significant Genes in Indolent Non-Hodgkin Lymphoma

ABL1 +

AFF1 +

ASXL1 +

BCL2 +

BCL6 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

NUP214 +

RPN1 +

RUNX1 +

TP53 +

Disease Details

Synonyms
Non-Hodgkin lymphoma, indolent, NOS, Indolent Non-Hodgkin's Lymphoma, NHL, indolent, NOS, indolent lymphoma
Parent(s)
Non-Hodgkin Lymphoma by Clinical Course
Children
Mycosis Fungoides, Marginal Zone Lymphoma, Primary Cutaneous Follicle Center Lymphoma, Diffuse Follicular Lymphoma, Lymphoplasmacytic Lymphoma, Grade 1 Follicular Lymphoma, Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation, Primary Cutaneous Anaplastic Large Cell Lymphoma, Grade 2 Follicular Lymphoma, and Subcutaneous Panniculitis-Like T-Cell Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.