Overview

Infiltrating renal pelvis and ureter urothelial carcinomas most frequently harbor alterations in TP53, KMT2D, FGFR3, KDM6A, and ARID1A [2].

Most Commonly Altered Genes in Infiltrating Renal Pelvis and Ureter Urothelial Carcinoma

TP53 Mutation, FGFR3 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KMT2D Mutation are the most common alterations in infiltrating renal pelvis and ureter urothelial carcinoma [2].

Top Alterations in Infiltrating Renal Pelvis and Ureter Urothelial Carcinoma

Significant Genes in Infiltrating Renal Pelvis and Ureter Urothelial Carcinoma

FGFR1 +

FGFR3 +

TSC1 +

TSC2 +

Disease Details

Synonyms
Infiltrating Renal Pelvis and Ureter Transitional Cell Carcinoma
Parent(s)
Renal Pelvis and Ureter Urothelial Carcinoma
Children
Infiltrating Renal Pelvis Urothelial Carcinoma, Sarcomatoid Variant
OncoTree Name
Upper Tract Urothelial Carcinoma
OncoTree Code
UTUC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.