Overview

NCI Definition: An advanced, invasive breast adenocarcinoma characterized by the presence of distinct changes in the overlying skin. These changes include diffuse erythema, edema, peau d'orange (skin of an orange) appearance, tenderness, induration, warmth, enlargement, and in some cases a palpable mass. The skin changes are the consequence of lymphatic obstruction from the underlying invasive breast adenocarcinoma. Microscopically, the dermal lymphatics show prominent infiltration by malignant cells. The invasive breast adenocarcinoma is usually of ductal, NOS type. There is not significant inflammatory cell infiltrate present, despite the name of this carcinoma. [1]

Inflammatory breast carcinomas most frequently harbor alterations in TP53, NOTCH2, MYC, MDM4, and MCL1 [2].

Most Commonly Altered Genes in Inflammatory Breast Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in inflammatory breast carcinoma [2].

Top Alterations in Inflammatory Breast Carcinoma

Significant Genes in Inflammatory Breast Carcinoma

ERBB2 +

Disease Details

Synonyms
Inflammatory Breast Cancer, Inflammatory Carcinoma of Breast, Mastitis Carcinomatosa, Inflammatory Carcinoma of the Breast
Parent(s)
Breast Adenocarcinoma
OncoTree Name
Inflammatory Breast Cancer
OncoTree Code
IBC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.