NCI Definition: A malignant neoplasm arising from the large blood vessels. It is characterized by the presence of tumor cells that grow within the lumen of the blood vessels. The intraluminal tumor growth may result in vascular obstruction and spread of tumor emboli to peripheral organs. The prognosis is usually poor. 
Intimal sarcomas most frequently harbor alterations in MDM2, TERT, and CDK4 .
MDM2 Amplification, TERT Amplification, and CDK4 Amplification are the most common alterations in intimal sarcoma .
There is 1 clinical trial for intimal sarcoma, of which 1 is open and 0 are completed or closed. Of the trial that contains intimal sarcoma as an inclusion criterion, 1 is phase 1/phase 2 (1 open).
Nivolumab and sunitinib are the most common interventions in intimal sarcoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.