NCI Definition: A malignant neoplasm arising from the large blood vessels. It is characterized by the presence of tumor cells that grow within the lumen of the blood vessels. The intraluminal tumor growth may result in vascular obstruction and spread of tumor emboli to peripheral organs. The prognosis is usually poor. [1]

Intimal sarcomas most frequently harbor alterations in MDM2, CDK4, TERT, PDGFRA, and KIT [2].

Most Commonly Altered Genes in Intimal Sarcoma

MDM2 Amplification, CDK4 Amplification, PDGFRA Amplification, KIT Amplification, and TERT Amplification are the most common alterations in intimal sarcoma [2].

Top Alterations in Intimal Sarcoma

Disease Details

Spindle Cell Sarcoma
OncoTree Name
Intimal Sarcoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.