Overview

NCI Definition: A myelodysplastic/myeloproliferative neoplasm of childhood that is characterized by proliferation principally of the granulocytic and monocytic lineages. Myelomonocytic proliferation is seen in the bone marrow and the blood. The leukemic cells may infiltrate any tissue, however liver, spleen, lymph nodes, skin, and respiratory tract are the most common sites of involvement. (WHO, 2001) [1]

Significant Genes in Juvenile Myelomonocytic Leukemia

ABL1 +

AFF1 +

BCR +

CBFA2T3 +

CBFB +

CREBBP +

DEK +

ELL +

ETV6 +

FLT3 +

GLIS2 +

HOXA9 +

KAT6A +

KDM5A +

KIT +

KMT2A +

KRAS +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

MYH11 +

NRAS +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

PTPN11 +

RPN1 +

RUNX1 +

RUNX1T1 +

TCF3 +

TP53 +

WT1 +

Disease Details

Synonyms
JMML, JCML, Juvenile Chronic Myeloid Leukemia, Juvenile Chronic Myelogenous Leukemia
Parent(s)
Myelodysplastic/Myeloproliferative Neoplasm
OncoTree Name
Juvenile Myelomonocytic Leukemia
OncoTree Code
JMML

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.