Overview

NCI Definition: A type of renal carcinoma affecting mostly young African-Americans. It is located in the medulla of the kidney, and follows an aggressive clinical course. Most reported cases have shown metastatic disease at the time of diagnosis. [1]

Kidney medullary carcinomas most frequently harbor alterations in VHL, TP53, SMARCB1, NFE2L2, and BAP1 [2].

VHL Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and TP53 Exon 8 Mutation are the most common alterations in kidney medullary carcinoma [2].

Significant Genes in Kidney Medullary Carcinoma

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.