NCI Definition: A type of renal carcinoma affecting mostly young African-Americans. It is located in the medulla of the kidney, and follows an aggressive clinical course. Most reported cases have shown metastatic disease at the time of diagnosis. [1]

Kidney medullary carcinomas most frequently harbor alterations in VHL, TP53, SMARCB1, NFE2L2, and BAP1 [2].

Most Commonly Altered Genes in Kidney Medullary Carcinoma

VHL Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and TP53 Exon 8 Mutation are the most common alterations in kidney medullary carcinoma [2].

Top Alterations in Kidney Medullary Carcinoma

Significant Genes in Kidney Medullary Carcinoma


Disease Details

Renal Medullary Carcinoma
Kidney Carcinoma
OncoTree Name
Renal Medullary Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.