NCI Definition: A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma. [1]

Kidney neoplasms most frequently harbor alterations in VHL, SETD2, TP53, BAP1, and MTOR [2].

Most Commonly Altered Genes in Kidney Neoplasm

VHL Mutation, SETD2 Mutation, TP53 Mutation, BAP1 Mutation, and TP53 Missense are the most common alterations in kidney neoplasm [2].

Top Alterations in Kidney Neoplasm

Disease Details

Neoplasm of Kidney, Renal Tumor, Renal Neoplasm, Tumor of the Kidney, Kidney Tumor, Renal Tumors, Tumor of Kidney, Neoplasm of the Kidney
Urinary System Neoplasm
Mixed Epithelial Stromal Tumor of the Kidney, Kidney Cancer, Renal Adenoma, Renal Neuroendocrine Tumor, Renal Oncocytoma, Kidney Angiomyolipoma, Renal Pelvis Neoplasm, Childhood Kidney Neoplasm, and Kidney Benign Neoplasm
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1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.