NCI Definition: A very rare small cell carcinoma that arises from the kidney. The prognosis is poor. [1]

Kidney small cell carcinomas most frequently harbor alterations in TSC2, TP53, SMC3, RB1, and PRKDC [2].

Most Commonly Altered Genes in Kidney Small Cell Carcinoma

TSC2 Q1536*, TSC2 Mutation, TP53 c.217-c.1178 Missense, TP53 V274L, and TP53 Mutation are the most common alterations in kidney small cell carcinoma [2].

Top Alterations in Kidney Small Cell Carcinoma

Disease Details

Renal Small Cell Carcinoma
Small Cell Carcinoma
OncoTree Name
Renal Small Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.