Kidney Wilms Tumor
NCI Definition: An embryonal pediatric tumor of the kidney which may also be seen rarely in adults. The peak incidence of Wilms tumor is between the second and fifth year of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, stromal, and epithelial). The most common sites of metastasis include the regional lymph nodes, lungs, and liver. 
Kidney Wilms tumors most frequently harbor alterations in TP53 and APC .
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and APC Mutation are the most common alterations in kidney Wilms tumor .
There is 1 clinical trial for kidney Wilms tumor, of which 1 is open and 0 are completed or closed. Of the trial that contains kidney Wilms tumor as an inclusion criterion, 1 is no phase specified (1 open).
Standard of care is the most common intervention in kidney Wilms tumor clinical trials.
Significant Genes in Kidney Wilms Tumor
MYCN is an inclusion eligibility criterion in 1 clinical trial for kidney Wilms tumor, of which 1 is open and 0 are closed. Of the trial that contains MYCN status and kidney Wilms tumor as inclusion criteria, 1 is no phase specified (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.